Ketamine in epilepsy treatment


  • Ketamine (KET) treatment is associated with decreased seizure burden and improved hemodynamics over time in patients with super-refractory status epilepticus (SRSE).

Why this matters

  • Super-refractory status epilepticus is associated with high mortality, and there is no available data supporting its optimal management.
  • Ketamine shows increased efficacy in SRSE treatment, with improved hemodynamics, and is relatively inexpensive; thus, incorporating it into early treatment plans for SRSE may provide significant benefits in outcomes for these patients, including decreased mortality rates.

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