Central nervous system manifestations of COVID-19 in children


  • There are clear acute- and delayed-phase patterns of neurological disease evident in children with SARS-CoV-2 infection, but more studies are needed.

Why this matters

  • Neurological complications of COVID-19 have been reported in numerous adult patients, including a high incidence of ischemic stroke and intracerebral hemorrhage.

  • In children, an inflammatory process during latency of SARS-CoV-2 has been reported, known as multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS).

  • It is understood that around 34% of children with MIS-C have neurological symptoms, but consolidated data on the central nervous system (CNS) manifestations of COVID-19 in children are lacking

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