A pre-clinical study of selinexor for primary central nervous system lymphoma

Takeaway

  • Selinexor blocks tumor growth, promotes an anti-tumor immune response, and increases survival in a mouse model of primary central nervous system lymphoma (PCNSL).

Why this matters

  • PCNSL is a rare and aggressive form of non-Hodgkin lymphoma, with limited treatment options and a 5-year survival rate of 30%.

  • Selinexor is a selective inhibitor of nuclear export which binds to cargo pocket of exportin XPO1 causing nuclear accumulation of tumor suppressor proteins and cell cycle regulators.

  • Selinexor may be a good candidate for the treatment of PCNSL; however, extensive pre-clinical and clinical trials would be needed to prove this.

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